生命科学学院

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郭小华


作者:郭小华    浏览次数:    责任编辑:    审核:    上传:    发布时间:2024-04-30

姓名:郭小华

职务/职称:教授,博士生导师

E-mail:guoxh@mail.scuec.edu.cn

一、学习及工作经历

2018/02-至今,永利集团88304官网,生命科学学院,教授

2011/06-2018/01,永利集团88304官网,生命科学学院,副教授

2008/03-2011/05,永利集团88304官网,生命科学学院,讲师

2006/09-2007/11,韩国农林部国立兽医科学检疫院细菌科,博士后

2003/8-2006/6,中国农业大学,动物营养与饲料科学,博士

2000/9-2003/6,中国农业大学,食品科学,硕士

1996/9-2000/6,长江大学,食品科学,学士

二、主要社会兼职

中国高科技产业化研究会饲料分会理事

三、科研活动及成果

(一)主要研究方向

1)工程益生菌的修饰和改造及其机制的研究;

2)益生菌、益生元和后生元的功能机制挖掘;

3)基于肠道稳态调控介导的细胞和动物研究技术;

4)基于AI+的活性蛋白和寡肽的分子挖掘、优化、机制及其合成生物学制造技术。

(二)主持的科研项目

1. 校级创新团队(2024-2026年)建设项目,XTZ24023,微生态工程及应用,2024/01-2026/12,45万元,主持

2. 企业横向合作项目,HZY23010,功能性碳水化合物功效研究,2024/01-2024/12,30万元,主持

3. 2023年湖北省科技人才服务企业项目,2023DJC120,人乳寡糖介导肠道稳态促进小鼠大脑发育和认知水平的效应及机制,2023,150万元,主持

4. 企业横向合作项目,HZY23010,功能性益生菌的开发与产业化应用,2023/01-2023/12,120万元,主持

5. 2022年度中央高校基本科研业务费重大培育项目,CZP22003,基于多组学解析益生芽孢杆菌对肠道稳态的调控机制,2022/04-2023/12,30万元,主持

6. 国家自然科学基金面上项目,32072767,L-Ala介导的益生芽孢杆菌对肠道屏障的保护机制,2021/01-2024/12,58万元,主持

7. 湖北省杰出青年人才项目,2018CFA077,CRISPR/Cas9介导的mKate基因定点敲入ETEC及其攻毒模型的构建,2018/01-2020/12,10万元,主持

8. 国家自然科学基金面上项目,31672455,饲用益生芽孢杆菌孢子体内萌发机制研究,2017/01-2020/12,62万元,结项,主持

(三)代表性论文

(1) Tianfei Yu, Tianshuo Hu, Kai Na, Li Zhang, Shuang Lu, Xiaohua Guo*. Glutamine-derived peptides: current progress and future directions. Comprehensive Reviews in Food Science and Food Safety, 2024. 23(4): e13386. doi: 10.1111/1541-4337.13386.

(2) Shuang Lu, Kai Na, Yuanrong Li, Li Zhang, Ying Fang, Xiaohua Guo*, Bacillus-derived probiotics: metabolites and mechanisms involved in bacterial-host interactions. Critical Reviews in Food Science and Nutrition, 2024. 64(6): 1701-1714. doi: 10.1080/10408398.2022.2118659.

(3) Ting Tao#, Li Zhang#, Tianfei Yu, Jiaxue Ma, Shuang Lu, Jing Ren, Xiangyu Li, Xiaohua Guo*, Exopolysaccharide production by Lactobacillus plantarum T10 is responsible for the probiotic activity in enhancing intestinal barrier function in vitro and in vivo. Food & Function. 2024. 15, 3583-3599. doi: 10.1039/d4fo00526k.

(4) Li Zhang, Jing Ren, Tianfei Yu, Yuanrong Li, Yanshun Li, Shuang Lu, Xiaohua Guo*, Supplementation of citrus pectin with whole-cell pectinase PG5 on Pichia pastoris promotes recovery of colitis and enhances intestinal barrier function in DSS-treated mice. International Journal of Biological Macromolecules, 2024. 312: 130476. doi: 10.1016/j.ijbiomac.2024.130476.

(5) Shuang Lu, Xianyin Liao, Wei Lu, Li Zhang, Kai Na, Xiangyu Li, Xiaohua Guo*, L-alanine promotes anti-infectious properties of Bacillus subtilis S-2 via the germination receptor-gerAA. Probiotics and Antimicrobial Proteins. 2024. 16:1399-1410. doi: 10.1007/s12602-023-10121-2.

(6) Shuang Lu, Kai Na, Jiani Wei, Ting Tao, Li Zhang, Ying Fang, Xiangyu Li, Xiaohua Guo*, Alginate oligosaccharide structures differentially affect DSS-induced colitis in mice by modulating gut microbiota. Carbohydrate Polymers, 2023. 312: 120806. doi: 10.1016/j.carbpol.2023.120806.

(7) Kai Na#, Jiani Wei#, Li Zhang, Xiangyu Li, Ying Fang, Lu Shuang*, Xiaohua Guo*, Effect of chitosan oligosaccharides (COS) and FMT from COS-dosed mice on the intestinal barrier function and cell apoptosis. Carbohydrate Polymers, 2022. 297: 120043. doi: 10.1016/j.carbpol.2022.120043.

(8) Shuang Lu, Ting Tao, Yating Su, Jia Hu, Li Zhang, Guoliang Wang, Xiangyu Li and Xiaohua Guo*. Whole genome sequencing and CRISPR/Cas9 gene editing of enterotoxigenic Escherichia coli BE311 for fluorescence labeling and enterotoxin analyses. International Journal of Molecular Sciences, 2022. 23(14), 7502; doi:10.3390/ijms23147502.

(9) Lu Shuang, Kai Na, Jiani Wei, Li Zhang, Guo Xiaohua*, Alginate oligosaccharides: the structure-function relationships and the directional preparation for application. Carbohydrate Polymers, 2022, 284: 119225. doi: 10.1016/j.carbpol.2022.119225.

(10) Lu Shuang, Liao Xianyin, Zhang Li, Fang Ying, Xiang Meixian, Guo Xiaohua*, Nutrient L-alanine-induced germination of Bacillus improves proliferation of spores and exerts probiotic effects in vitro and in vivo. Frontiers in Microbiology, 2021, 12:796158. doi: 10.3389/fmicb.2021.796158.

(11) Ya-ting Su, Chun Liu, Zhu Long, Hang Ren, Xiao-hua Guo*, Improved production of spores and bioactive metabolites from Bacillus amyloliquefaciens in solid-state fermentation by a rapid optimization process, Probiotics and Antimicrobial Proteins, 2019, 11(3): 921-930.

(12) Xiao-Sheng Liang, Chun Liu, Zhu Long, Xiao-Hua Guo*, Rapid and simple detection of endospore counts in probiotic Bacillus cultures using dipicolinic acid (DPA) as a marker, AMB Express, 2018, 8:101.

(13) Hang Ren, Ya-ting Su, Xiao-hua Guo*, Rapid optimization of spore production from Bacillus amyloliquefaciens in submerged cultures based on dipicolinic acid fluorimetry assay, AMB Express, 2018, 8:21

(14) Yating Su, Xingjie Chen, Ming Liu, Xiaohua Guo*, Effect of three lactobacilli with strain-specific activities on the growth performance, faecal microbiota and ileum mucosa proteomics of piglets, Journal of Animal Science and Biotechnology, 2017, 8:52:916-924

(四)授权专利

(1) 郭小华,卢霜,韦嘉妮,纳凯,陶婷. 磷脂酰胆碱在制备用于抗神经性炎症的食品或药品中的应用. 202310178894.2

(2) 郭小华,卢霜,纳凯,韦嘉妮,陶婷. 一种缓解肠道屏障损伤和炎症的药物. 202310178895.7

(3) 郭小华,卢霜,陶婷,纳凯,韦嘉妮. 1,6-脱水-β-D-葡萄糖制备用于维持结肠上皮屏障和隐窝的完整性以及抗结肠炎的食品药品的应用. 2023101789004

(4) 郭小华,胡佳,张莉,卢霜,一种大肠杆菌Escherichia coli ETEC BE-311菌株及其应用,2022.05.17,中国,ZL 2020 1 1533828.5

(5) 郭小华,胡佳,张莉,卢霜,大肠杆菌Escherichia coli ETEC BE-311-faeG及应用,2022.05.17,中国,ZL 2020 1 1522510.7

(6) 郭小华,任航,苏雅婷,一种采用响应面法快速优化金属离子促进芽孢产孢的方法,2021.02.02,中国,ZL 2017 1 1085131.4

(7) 郭小华,任航,苏雅婷,龙祝,刘纯,一种高浓度芽孢杆菌饲料添加剂的简易制备方法,2021.02.02,中国,ZL 2018 1 0497569.1

(8) 郭小华,苏雅婷,梁晓声,张莉,一种肠毒性大肠杆菌的特异性标记方法,2020.08.25,中国,ZL 2018 1 1191215.0

(9) 郭小华,杨菁菁,字春丽,陈沙,一种快速定量检测芽孢杆菌发酵液中营养体和芽孢体的方法,2019.03.01,中国,ZL 2016 1 1010404.4.

(10) 郭小华,熊海容,刘虹,覃瑞,一种从山药中提取山药粘蛋白的工艺,2013.06.19,中国,ZL2012 1 0173796.1

四、教学活动及成果

(一)承担课程

《生命科学导论》,《发酵工程与设备模块实验》、《生物分离工程模块实验》、《食品化学》

(二)教学成果

主持生物工程省级一流专业建设和工程教育认证