姓名：马立群

职务/职称：副教授（硕导）

通讯地址：永利集团88304官网生命科学学院8号楼8D301

E-mail：ma.liqun@hotmail.com

研究领域和方向

主要从事呼吸循环系统重大疾病发病机理的研究以及新药研发。近年来重点研究心血管疾病与代谢性疾病的分子生物学机制，民族药物的药理学与毒理学。

教育背景

2002.09—2008.06华中科技大学同济医学院，药理学博士

1997.09—2002.06三峡大学医学院，临床医学学士

工作简历

2014.07—至今永利集团88304官网生命科学学院，讲师

2008.09—2014.06美国纽约大学奥本尼分校，博士后、资深研究员

近年来主持或参与的科研项目

1. 主持：国家自然科学基金青年项目（81500253），TASK-1双孔钾离子通道在酸中毒诱发心律失常中的病理作用，2016/01-2018/12

2. 主持：国家民委自然科学基金一般项目（14ZNZ021），武陵山区苦味中药黄柏提取物抗

哮喘的作用机理研究及开发，2015/01-2016/12

发表论文（#并列第一作者，通讯作者）

1. He Caijing#,Ma Liqun#,Muhammad Sarfaraz Iqbal, Huang Xianju*, Jun Li, Yang Guangzhogn,Awais Ihsan.Veratrilla baillonii Franchexerts anti-diabetic activity andimproves liver injury throughIRS/PI3K/AKTsignalingpathways in type 2 diabeticdb/db mice. Journal of functional foods. Accepted.

2. Qiu Junying#,Ma Liqun#, Liu Beibei, Zhang Wenjing, et al.Folium Sennae and emodin reverse airway smooth muscle contraction. Cell Biol Int.2020 Sep;44(9):1870-1880.

3. Qin Xuhui#, Wang Haixia#,Ma Liqun#, Shen Jinhua, Liu Qinghua, Xue Lu*.Knockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell. Cell Biochemistry and Biophysics.Published on06November 2019.

4. She Yushan#,Ma Liqun#, Liu Beibei, Zhang Wenjing, et al. Semen cassiae Extract Inhibits Contraction of Airway Smooth Muscle. Frontiers in Pharmacology. Published on04December 2018.

5.Ma Liqun#, Yu You#, Li Mei, Ihsan Awais, Tong Haiying, Huang Xianju* and Gao Yue. Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line. Frontiers in Pharmacology. Published on05November 2018.

6. Ouyang Cong, Pu Yizhi, Qin Xuhui, Shen Jinhua, Liu Qinghua,Ma Liqun* and Xue Lu*. Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells. BIOSCIENCE REPORTS.Published on04December 2018.

7. Huang Jun#, Ma Liqun#, Yang Yongle,Wen Nana, Zhou Wan, Cai Congli, Liu Qinghua*,Shen Jinhua*. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. Published on Nov 2017.

8.Ma Liqun,Zhang X, Zhou M,Chen H*. Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification.J Biol Chem. 2012, 287(44):37145-53.

9. Ma Liqun,Xie YP, Zhou M, Chen H*. Silent TWIK-1 Potassium Channels Conduct Monovalent Cation Currents. Biophysical Journal. 2012, 102:L34–L36.

10.Ma Liqun,Zhang X,Chen H*. TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.Sci Signal. 2011, 7; 4(176):ra37.

11.Ma Liqun,Liu C,Wang F,Xie N,Gu J,Chen JG*. Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.J Neurophysiol. 2009, 101(5):2230-8.

12. Haijun Chen#*, DongchuanZuo, JianingZhang, Min Zhou,Ma Liqun. Classification of 2-pore domain potassium channels based on rectification under quasi-physiological ionicconditions. Channels, 2014, 8(6): 503-508.

13. Zhou M#, Xu G, Xie M, Zhang X, Schools GP,Ma Liqun, Kimelberg HK, Chen HJ*. TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. Journal of Neuroscience. 2009, 29:8551-8564.

14. Chen HJ#, Kronengold J, Yan Y, Gazula VR, Brown MR,Ma Liqun, Ferreira G, Yang Y, Bhattacharjee A, Sigworth FJ, Salkoff L, Kaczmarek LK*. The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. Journal of Neuroscience. 2009, 29:5654-5665.

承担课程

动物学、发育生物学、药理学、营养学等。